The Fort Mohave Indian Reservation is an Indian reservation along the Colorado River, currently encompassing 23,669 acres in Arizona, 12,633 acres in California, and 5,582 acres in Nevada. The reservation is home to approximately 1,100 members of the federally recognized Fort Mojave Indian Tribe of Arizona, California, and Nevada, a federally recognized tribe of Mohave people.

Native Americans occupy less than 50 percent of the Mojave reservation. The Mohave people have leased much of their land to cotton, corn, and soybean farming companies, which employ a large population of resident European-Americans and Mexican Americans.

The site of the former Fort Mohave and the eastern terminus of the Mojave Road are situated within the Fort Mojave Indian Reservation.

These lands were occupied for thousands of years by succeeding cultures of Indigenous peoples. The property covers areas along the Colorado River of the three adjacent states of Arizona, California, and Nevada. It also is sporadically traversed by the Mojave River in California.

The Fort Mohave Indian Reservation was established in 1890, and comprised the land of the former camp Mojave military reservation, thereby transferring it from the War Department to the Office of Indian Affairs. For decades until the early 1930s, it operated an Indian boarding school for Native American students from the Mohave and other tribes, as part of efforts to assimilate youth to the mainstream culture. They were forced to speak English and practice Christianity while at the school. The property was transferred to the reservation in 1935.